Acetone → 1937215-88-7

HRID 1374854Notes

Reaction equation

HRID 1374854 reaction equation
[ClH:1].[F:2][C:3]1[CH:8]=[CH:7][C:6]([C:9](=[O:28])[CH2:10][N:11]2[CH2:16][CH2:15][CH:14]([CH2:17][N:18]3[CH2:26][C:25]4[C:20](=[CH:21][CH:22]=[CH:23][CH:24]=4)[C:19]3=[O:27])[CH2:13][CH2:12]2)=[CH:5][CH:4]=1.O.CC(C)=[O:32]>C(OCC)(=O)C>[OH2:27].[OH2:32].[ClH:1].[F:2][C:3]1[CH:8]=[CH:7][C:6]([C:9](=[O:28])[CH2:10][N:11]2[CH2:12][CH2:13][CH:14]([CH2:17][N:18]3[CH2:26][C:25]4[C:20](=[CH:21][CH:22]=[CH:23][CH:24]=4)[C:19]3=[O:27])[CH2:15][CH2:16]2)=[CH:5][CH:4]=1

Participants

5

Reactant 3

HCID 180AcetoneHCID 962WaterHCID 21078079359625-80-22×

Product 1

HCID 210780801937215-88-7Yield 79%

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Conditions

Temperature
60 °C

Procedure

2-[[1-[2-(4-Fluorophenyl)-2-oxoethyl]piperidin-4-yl]methyl]isoindolin-1-one hydrochloride (the compound of Example 1, 39.4 mmol) was added to water (30 mL) and acetone (210 mL), and mixture was heated at 60° C. for dissolution. The mixture was added dropwise with ethyl acetate (100 mL) and stand for cooling to room temperature. The crystals precipitated were collected by filtration and the resulting crystals were washed with ethyl acetate and dried under reduced pressure to obtain the title compound (yield: 79%).

Workup

  1. temperaturefor cooling to room temperature
  2. customThe crystals precipitated
  3. filtrationwere collected by filtration
  4. washthe resulting crystals were washed with ethyl acetate
  5. customdried under reduced pressure

Sources & evidence

ORD record
ord-fb872da5c1e5452ab3504350e2f68b5d
Source dataset
uspto-grants-2007_01
Patent number
US07166617B2

Reaction notes

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