Hydrochloric Acid → 5-Amino-2-methoxy-5-methylhex-3-yne hydrochloride

HRID 1374909Notes

Reaction equation

HRID 1374909 reaction equation
[CH3:1][O:2][CH:3]([C:5]#[C:6][C:7]([N:10]1[Si](C)(C)CC[Si]1(C)C)([CH3:9])[CH3:8])[CH3:4].[ClH:19]>>[ClH:19].[NH2:10][C:7]([CH3:9])([CH3:8])[C:6]#[C:5][CH:3]([O:2][CH3:1])[CH3:4]

Participants

3

Reactant 2

HCID 313Hydrochloric AcidHCID 21078409(2-Methoxy-5-methylhex-3-yn-5-yl)-2,2,5,5-tetramethyl-1-aza-2,5-disilacyclopentane

Product 1

HCID 210784255-Amino-2-methoxy-5-methylhex-3-yne hydrochloride

Procedure

(2-Methoxy-5-methylhex-3-yn-5-yl)-2,2,5,5-tetramethyl-1-aza-2,5-disilacyclopentane (1.2 g) was stirred with dilute aqueous hydrochloric acid (12 ml) for 0.25 hours. The aqueous phase was washed with diethyl ether (twice) and the evaporated under reduced pressure. The residue was evaporated with toluene (twice) to remove residual water to give 5-amino-2-methoxy-5-methylhex-3-yne hydrochloride, 0.54 g, as a yellow solid.

Workup

  1. washThe aqueous phase was washed with diethyl ether (twice) and the
  2. customevaporated under reduced pressure
  3. customThe residue was evaporated with toluene (twice)
  4. customto remove residual water

Sources & evidence

ORD record
ord-f4899fa024e248c28d01fcf05223a0e6
Source dataset
uspto-grants-2007_01
Patent number
US07166621B2

Reaction notes

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