Benzyl Bromide → HCID 69473827, compound

HRID 1374937Notes

Reaction equation

HRID 1374937 reaction equation
[O:1]1[CH:5]=[CH:4][N:3]=[CH:2]1.[CH2:6]([Br:13])[C:7]1[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=1>>[Br-:13].[CH2:6]([N+:3]1[CH:4]=[CH:5][O:1][CH:2]=1)[C:7]1[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=1

Participants

3

Reactant 2

HCID 7498Benzyl BromideHCID 9255Oxazole

Product 1

HCID 69473827HCID 69473827, compound

Procedure

2 g oxazole was reacted with 4.95 g benzyl bromide at room temperature for 2 hours and then overnight at 50° C. On cooling to room temperature, solids were filtered and dried. The yield was 3.1 g. The material was dissolved in ethanol and recrystalized with MTBE. The recrystallized compound had a melting point of 177–180° C. and proton NMR spectra consistent with the structure 3-benzyl-oxazol-3-ium bromide. On analysis the compound contained 50.00% C, 4.04% H, 36.36% Br, and 5.08% N.

Workup

  1. customovernight
  2. customat 50° C
  3. filtrationsolids were filtered
  4. customdried
  5. dissolutionThe material was dissolved in ethanol
  6. customrecrystalized with MTBE

Sources & evidence

ORD record
ord-fea0e6d6bedd469f82ee43a993670733
Source dataset
uspto-grants-2007_01
Patent number
US07166625B2

Reaction notes

Loading…