Phenyl isocyanate → HCID 21079259, compound

HRID 1374939Notes

Reaction equation

HRID 1374939 reaction equation
[C:1]1([N:7]=[C:8]=[O:9])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[NH2:10][C:11]1[C:19]2[C:14](=[CH:15][C:16]([Cl:26])=[C:17]([C:20]3[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=3)[CH:18]=2)[N:13]([CH2:27][O:28][CH2:29][CH2:30][Si:31]([CH3:34])([CH3:33])[CH3:32])[N:12]=1>O1CCCC1>[Cl:26][C:16]1[CH:15]=[C:14]2[C:19]([C:11]([NH:10][C:8]([NH:7][C:1]3[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=3)=[O:9])=[N:12][N:13]2[CH2:27][O:28][CH2:29][CH2:30][Si:31]([CH3:34])([CH3:33])[CH3:32])=[CH:18][C:17]=1[C:20]1[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=1

Participants

4

Reactant 2

HCID 7672Phenyl isocyanateHCID 21079252HCID 21079252, compound

Product 1

HCID 21079259HCID 21079259, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

39 μl of phenyl isocyanate are added to a solution of 102.2 mg of 3-amino-5-phenyl-6-chloro-1-[(2-trimethylsilylethoxy)methyl]indazole in 2.5 cm3 of tetrahydrofuran. The reaction medium is stirred at ambient temperature for 24 hours and is then evaporated. Purification of the crude product by chromatography on silica (eluant: methylene chloride/acetone (98/2, v/v)) makes it possible to obtain 122.5 mg of 1-[6-chloro-5-phenyl-1-(2-trimethylsilanylethoxymethyl)-1H-indazol-3-yl]-3-phenylurea (colorless solid).

Workup

  1. customis then evaporated
  2. customPurification of the crude product by chromatography on silica (eluant

Sources & evidence

ORD record
ord-c353b37507f5450897e75a4006b3e65b
Source dataset
uspto-grants-2007_01
Patent number
US07166629B2

Reaction notes

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