Hydrochloric Acid → HCID 10248119, compound

HRID 1374940Notes

Reaction equation

HRID 1374940 reaction equation
Cl.[Cl:2][C:3]1[CH:11]=[C:10]2[C:6]([C:7]([NH:20][C:21]([NH:23][C:24]3[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=3)=[O:22])=[N:8][N:9]2COCC[Si](C)(C)C)=[CH:5][C:4]=1[C:30]1[CH:35]=[CH:34][CH:33]=[CH:32][CH:31]=1>CO>[Cl:2][C:3]1[CH:11]=[C:10]2[C:6]([C:7]([NH:20][C:21]([NH:23][C:24]3[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=3)=[O:22])=[N:8][NH:9]2)=[CH:5][C:4]=1[C:30]1[CH:35]=[CH:34][CH:33]=[CH:32][CH:31]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 21079259HCID 21079259, compound

Product 1

HCID 10248119HCID 10248119, compoundYield 105.1%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

1 ml of 2N HCl is added to a solution of 106 mg of 1-[6-chloro-5-phenyl-1-(2-trimethylsilanylethoxymethyl)-1H-indazol-3-yl]-3-phenylurea in 12 cm3 of methanol. The reaction medium is stirred at ambient temperature for 48 hours and at reflux for 5 hours, then evaporated. The solid obtained is dried under vacuum to give 82 mg of N-(6-chloro-5-phenyl-1H-indazol-3-yl)-N′-phenylurea (colorless solid).

Workup

  1. temperatureat reflux for 5 hours
  2. customevaporated
  3. customThe solid obtained
  4. customis dried under vacuum

Sources & evidence

ORD record
ord-f764bb0a32ce495c86eff59dd9680f79
Source dataset
uspto-grants-2007_01
Patent number
US07166629B2

Reaction notes

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