HuagongsheHuagongshe Chemistry Print Report · For research reference only
Acetic Acid → HCID 10473045, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Acetic Acid | HCID 176 | — |
| Reactant | 3,5-Difluoroaniline | HCID 96595 | — |
| Reactant | HCID 21079382 | HCID 21079382 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | HCID 10473045 | HCID 10473045 | — |
Reaction Steps
A mixture of 1-(4-hydroxyphenyl)-1H-indole-2,3-dione (30 mg, 0.126 mmol), 3,5-difluoroaniline (170 mg, 1.32 mmol), and a drop of acetic acid was heated at 140° C. for 4 hours in a 3 mL vial. The crude product was suspended in CH2Cl2 and purified by preparative TLC [Eluent: EtOAc/hexane (1:1)] giving the desired product. Procedure D
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07166635B2 |
| Source dataset | uspto-grants-2007_01 |
| ORD ID | ord-f2b0958e1be54543bc1023299ff7792d |
| Source note | uspto-grants-2007_01 |