Hydrochloric Acid → HCID 69417094, compound

HRID 1374981Notes

Reaction equation

HRID 1374981 reaction equation
C([N:8]1[C@@H:13]([CH3:14])[CH2:12][O:11][C@H:10]([CH2:15][O:16][CH3:17])[CH2:9]1)C1C=CC=CC=1.[ClH:18]>[C].[Pd].CO>[ClH:18].[CH3:17][O:16][CH2:15][C@H:10]1[O:11][CH2:12][C@H:13]([CH3:14])[NH:8][CH2:9]1

Participants

5

Reactant 2

HCID 313Hydrochloric AcidHCID 57015382HCID 57015382, compound

Product 1

HCID 69417094HCID 69417094, compound

Reagents, catalysts & solvents 2

HCID 178418390HCID 178418390, compoundCatalystHCID 887MethanolSolvent

Procedure

A solution of (2S,5S)-4-benzyl-2-methoxymethyl-5-methylmorpholine (0.86 g) in a mixture of concentrated hydrochloric acid (0.31 ml) and methanol (8.6 ml) was hydrogenated over 10% palladium-carbon (50% wet, 0.2 g) at room temperature under atmospheric pressure for 3 hours. After removal of the catalyst by filtration through Celite®, the filtrate was concentrated under reduced pressure to give (2S,5S)-2-methoxymethyl-5-methylmorpholine hydrochloride (0.71 g) as an oil.

Workup

  1. customAfter removal of the catalyst
  2. filtrationby filtration through Celite®
  3. concentrationthe filtrate was concentrated under reduced pressure

Sources & evidence

ORD record
ord-a9716628fb2b49429f79ee8480cb82d9
Source dataset
uspto-grants-2007_01
Patent number
US07166598B2

Reaction notes

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