Hydrochloric Acid → HCID 21076988, compound

Participants

Reaction Steps

A solution of 1-[3,5-bis(trifluoromethyl)benzoyl]-2-(3-hydroxy-4-methylbenzyl)-4-[3-(3-pyridyl)-2-propynyl]-piperazine (0.11 g) in methanol (10 ml) was treated with 4N hydrogen chloride in ethyl acetate (1 ml) and the mixture was evaporated under reduced pressure. The residue was triturated with a mixture of dichloromethane and ethyl acetate and the resulting powder was collected by filtration to give 1-[3,5-bis(trifluoromethyl)benzoyl]-2-(3-hydroxy-4-methylbenzyl)-4-[3-(3-pyridyl)-2-propynyl]piperazine dihydrochloride (0.07 g).

Provenance & Evidence