Hydrochloric Acid → HCID 21076988, compound

HRID 1374992Notes

Reaction equation

HRID 1374992 reaction equation
[F:1][C:2]([F:40])([F:39])[C:3]1[CH:4]=[C:5]([CH:32]=[C:33]([C:35]([F:38])([F:37])[F:36])[CH:34]=1)[C:6]([N:8]1[CH2:13][CH2:12][N:11]([CH2:14][C:15]#[C:16][C:17]2[CH:18]=[N:19][CH:20]=[CH:21][CH:22]=2)[CH2:10][CH:9]1[CH2:23][C:24]1[CH:29]=[CH:28][C:27]([CH3:30])=[C:26]([OH:31])[CH:25]=1)=[O:7].[ClH:41]>CO.C(OCC)(=O)C>[ClH:41].[ClH:41].[F:39][C:2]([F:1])([F:40])[C:3]1[CH:4]=[C:5]([CH:32]=[C:33]([C:35]([F:36])([F:37])[F:38])[CH:34]=1)[C:6]([N:8]1[CH2:13][CH2:12][N:11]([CH2:14][C:15]#[C:16][C:17]2[CH:18]=[N:19][CH:20]=[CH:21][CH:22]=2)[CH2:10][CH:9]1[CH2:23][C:24]1[CH:29]=[CH:28][C:27]([CH3:30])=[C:26]([OH:31])[CH:25]=1)=[O:7]

Participants

5

Reactant 2

HCID 313Hydrochloric AcidHCID 9872559HCID 9872559, compound

Product 1

HCID 21076988HCID 21076988, compound

Reagents, catalysts & solvents 2

HCID 887MethanolSolventHCID 8857Ethyl AcetateSolvent

Procedure

A solution of 1-[3,5-bis(trifluoromethyl)benzoyl]-2-(3-hydroxy-4-methylbenzyl)-4-[3-(3-pyridyl)-2-propynyl]-piperazine (0.11 g) in methanol (10 ml) was treated with 4N hydrogen chloride in ethyl acetate (1 ml) and the mixture was evaporated under reduced pressure. The residue was triturated with a mixture of dichloromethane and ethyl acetate and the resulting powder was collected by filtration to give 1-[3,5-bis(trifluoromethyl)benzoyl]-2-(3-hydroxy-4-methylbenzyl)-4-[3-(3-pyridyl)-2-propynyl]piperazine dihydrochloride (0.07 g).

Workup

  1. customthe mixture was evaporated under reduced pressure
  2. customThe residue was triturated with a mixture of dichloromethane and ethyl acetate
  3. filtrationthe resulting powder was collected by filtration

Sources & evidence

ORD record
ord-6952d327dc7d4cf9b2dc3e66a7ca0934
Source dataset
uspto-grants-2007_01
Patent number
US07166598B2

Reaction notes

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