Hydrochloric Acid → 3-Methoxy-4-(trifluoromethyl)benzoic acid

HRID 1375000Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1375000
[CH3:1][O-:2].[Na+].F[C:5]1[CH:6]=[C:7]([CH:11]=[CH:12][C:13]=1[C:14]([F:17])([F:16])[F:15])[C:8]([OH:10])=[O:9].Cl>CO.CS(C)=O>[CH3:1][O:2][C:5]1[CH:6]=[C:7]([CH:11]=[CH:12][C:13]=1[C:14]([F:17])([F:16])[F:15])[C:8]([OH:10])=[O:9]

Komponenten

6

Edukt 3

HCID 313Hydrochloric AcidHCID 6882933-Fluoro-4-(trifluoromethyl)benzoic acidHCID 10942334Sodium Methoxide

Produkt 1

HCID 179641303-Methoxy-4-(trifluoromethyl)benzoic acid

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 679Dimethyl SulfoxideLösungsmittelHCID 887MethanolLösungsmittel

Reaktionsbedingungen

Temperatur
90 °C

Versuchsvorschrift

28% Sodium methoxide in methanol (50 ml) was added to a solution of 3-fluoro-4-(trifluoromethyl)benzoic acid (20.8 g) in dimethylsulfoxide (200 ml). The mixture was stirred at 90° C. for 3.5 hours. After cooling at room temperature, the resulting mixture was poured into ice-water (1.5 l) and made acidic with diluted hydrochloric acid. After being stirred for 30 minutes, the resulting precipitates were collected by filtration and air-dried to give a colorless powder of 3-methoxy-4-(trifluoromethyl)benzoic acid (22.95 g).

Aufarbeitung

  1. temperatureAfter cooling at room temperature
  2. stirringAfter being stirred for 30 minutes
  3. customthe resulting precipitates
  4. filtrationwere collected by filtration
  5. customair-dried

Quellen und Nachweise

ORD-Eintrag
ord-79b94773e547468884048af591b46819
Quelldatensatz
uspto-grants-2007_01
Patentnummer
US07166598B2

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