Ammonium Hydroxide → 151104-74-4

HRID 1375021Notes

Reaction equation

HRID 1375021 reaction equation
Cl[S:2]([C:5]1[CH:6]=[C:7]([CH:11]=[C:12]([C:14]([F:17])([F:16])[F:15])[CH:13]=1)[C:8]([OH:10])=[O:9])(=[O:4])=[O:3].[NH4+:18].[OH-]>>[S:2]([C:5]1[CH:6]=[C:7]([CH:11]=[C:12]([C:14]([F:17])([F:16])[F:15])[CH:13]=1)[C:8]([OH:10])=[O:9])(=[O:4])(=[O:3])[NH2:18]

Participants

3

Reactant 2

HCID 14923Ammonium HydroxideHCID 189524913-(Chlorosulfonyl)-5-(trifluoromethyl)benzoic acid

Product 1

HCID 18952486151104-74-4

Conditions

Temperature
0 °C

Procedure

To a 3-chlorosulfonyl-5-(trifluoromethyl)benzoic acid (0.4 g) was added 28% ammonia aqueous solution (5.0 ml) at 0° C. The mixture was stirred at 0° C., and then allowed to stand at room temperature overnight. The mixture was concentrated to dryness, and then 1N hydrochloric acid (5 ml) was added to the mixture, and stirred at 0° C. for 30 minutes. The resulted powder was collected by filtration and dried under reduced pressure to give 3-sulfamoyl-5-(trifluoromethyl)benzoic acid (299.4 mg) as a pale yellow powder.

Workup

  1. concentrationThe mixture was concentrated to dryness
  2. addition1N hydrochloric acid (5 ml) was added to the mixture
  3. stirringstirred at 0° C. for 30 minutes
  4. filtrationThe resulted powder was collected by filtration
  5. customdried under reduced pressure

Sources & evidence

ORD record
ord-10a0bce0a48e408abc4fd1570921e7f1
Source dataset
uspto-grants-2007_01
Patent number
US07166598B2

Reaction notes

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