反应详情

温度

0 °C

To a 3-chlorosulfonyl-5-(trifluoromethyl)benzoic acid (0.4 g) was added 28% ammonia aqueous solution (5.0 ml) at 0° C. The mixture was stirred at 0° C., and then allowed to stand at room temperature overnight. The mixture was concentrated to dryness, and then 1N hydrochloric acid (5 ml) was added to the mixture, and stirred at 0° C. for 30 minutes. The resulted powder was collected by filtration and dried under reduced pressure to give 3-sulfamoyl-5-(trifluoromethyl)benzoic acid (299.4 mg) as a pale yellow powder.

1. concentrationThe mixture was concentrated to dryness
2. addition1N hydrochloric acid (5 ml) was added to the mixture
3. stirringstirred at 0° C. for 30 minutes
4. filtrationThe resulted powder was collected by filtration
5. customdried under reduced pressure