Pyrrolidine → HCID 17964234, compound

HRID 1375023Notes

Reaction equation

HRID 1375023 reaction equation
Cl[S:2]([C:5]1[CH:6]=[C:7]([CH:11]=[C:12]([C:14]([F:17])([F:16])[F:15])[CH:13]=1)[C:8]([OH:10])=[O:9])(=[O:4])=[O:3].[NH:18]1[CH2:22][CH2:21][CH2:20][CH2:19]1>ClCCl>[N:18]1([S:2]([C:5]2[CH:6]=[C:7]([CH:11]=[C:12]([C:14]([F:17])([F:16])[F:15])[CH:13]=2)[C:8]([OH:10])=[O:9])(=[O:4])=[O:3])[CH2:22][CH2:21][CH2:20][CH2:19]1

Participants

4

Reactant 2

HCID 31268PyrrolidineHCID 189524913-(Chlorosulfonyl)-5-(trifluoromethyl)benzoic acid

Product 1

HCID 17964234HCID 17964234, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

A solution of a mixture of 3-chlorosulfonyl-5-trifluoromethylbenzoic acid (0.5 g) and pyrrolidine (0.72 ml) in dichloromethane (5 ml) was stirred at room temperature overnight. After evaporation to dryness, water (50 ml) was added to the residue and adjusted to pH 1.0 by 1N hydrochloric acid. The resulting precipitates were collected by filtration, and dried under reduced pressure at 45° C. to give 3-(pyrrolidinosulfonyl)-5-(trifluoromethyl)benzoic acid (0.514 g) as a powder.

Workup

  1. customAfter evaporation to dryness, water (50 ml)
  2. additionwas added to the residue
  3. customThe resulting precipitates
  4. filtrationwere collected by filtration
  5. customdried under reduced pressure at 45° C.

Sources & evidence

ORD record
ord-df84acdf60f942d7baa568a3d7487eec
Source dataset
uspto-grants-2007_01
Patent number
US07166598B2

Reaction notes

Loading…