Hydrochloric Acid → HCID 69419322, compound

Participants

Reaction Steps

4N Hydrogen chloride in 1,4-dioxane solution (9 ml) was added to an ice-cooled solution of (2R)-2-(tert-butyloxycarbonylamino)-3-(4-hydroxy-3-methoxyphenyl)propionic acid benzyl ester (2.90 g) in dichloromethane (29 ml). After being stirred at the same temperature for 2 hours, the mixture was concentrated under reduced pressure to give (2R)-2-amino-3-(4-hydroxy-3-methoxyphenyl)propionic acid benzyl ester hydrochloride (2.8 g) as an oil.

Provenance & Evidence