Hydrochloric Acid → HCID 69419322, compound

HRID 1375036Notes

Reaction equation

HRID 1375036 reaction equation
[ClH:1].[CH2:2]([O:9][C:10](=[O:30])[C@H:11]([NH:22]C(OC(C)(C)C)=O)[CH2:12][C:13]1[CH:18]=[CH:17][C:16]([OH:19])=[C:15]([O:20][CH3:21])[CH:14]=1)[C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][CH:4]=1>O1CCOCC1.ClCCl>[ClH:1].[CH2:2]([O:9][C:10](=[O:30])[C@H:11]([NH2:22])[CH2:12][C:13]1[CH:18]=[CH:17][C:16]([OH:19])=[C:15]([O:20][CH3:21])[CH:14]=1)[C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][CH:4]=1

Participants

5

Reactant 2

HCID 313Hydrochloric AcidHCID 54194702HCID 54194702, compound

Product 1

HCID 69419322HCID 69419322, compound

Reagents, catalysts & solvents 2

HCID 6344DichloromethaneSolventHCID 312751,4-DioxaneSolvent

Procedure

4N Hydrogen chloride in 1,4-dioxane solution (9 ml) was added to an ice-cooled solution of (2R)-2-(tert-butyloxycarbonylamino)-3-(4-hydroxy-3-methoxyphenyl)propionic acid benzyl ester (2.90 g) in dichloromethane (29 ml). After being stirred at the same temperature for 2 hours, the mixture was concentrated under reduced pressure to give (2R)-2-amino-3-(4-hydroxy-3-methoxyphenyl)propionic acid benzyl ester hydrochloride (2.8 g) as an oil.

Workup

  1. concentrationthe mixture was concentrated under reduced pressure

Sources & evidence

ORD record
ord-aa7aab8ed5fd47209e5659d693d09312
Source dataset
uspto-grants-2007_01
Patent number
US07166598B2

Reaction notes

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