反应详情

4N Hydrogen chloride in 1,4-dioxane solution (48 ml) was added dropwise to a solution of N-benzyl-N-benzyloxycarbonylmethyl-(2R)-2-(tert-butoxycarbonylamino)-3-(4-methoxyphenyl)propionamide (8.48 g) in dichloromethane (48 ml) under ice-bath cooling. After being stirred for 2 hours at the same temperature, the reaction mixture was concentrated under reduced pressure. The residue was added to aqueous sodium bicarbonate solution (50 ml) and dichloromethane (50 ml), and the organic layer was separated, washed with brine, dried over sodium sulfate, and evaporated under reduced pressure to give a powder of (3R)-1-benzyl-3-(4-methoxybenzyl)piperazine-2,5-dione (3.65 g).

1. temperaturecooling
2. concentrationthe reaction mixture was concentrated under reduced pressure
3. additionThe residue was added to aqueous sodium bicarbonate solution (50 ml) and dichloromethane (50 ml)
4. customthe organic layer was separated
5. washwashed with brine
6. dry with materialdried over sodium sulfate
7. customevaporated under reduced pressure