(Trifluoromethyl)benzene → HCID 69265480, compound

HRID 1375061Notes

Reaction equation

HRID 1375061 reaction equation
[F:1][C:2]([F:10])([F:9])[C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][CH:4]=1.[NH2:11][C:12]1[CH:16]=[C:15](Cl)[S:14][C:13]=1[S:18]([NH2:21])(=[O:20])=[O:19]>>[NH2:11][C:12]1[CH:16]=[C:15]([C:6]2[CH:7]=[CH:8][C:3]([C:2]([F:10])([F:9])[F:1])=[CH:4][CH:5]=2)[S:14][C:13]=1[S:18]([NH2:21])(=[O:20])=[O:19]

Participants

3

Reactant 2

HCID 7368(Trifluoromethyl)benzeneHCID 109559343-Amino-5-chlorothiophene-2-sulfonamide

Product 1

HCID 69265480HCID 69265480, compound

Procedure

The title compound was prepared from 4-trifluoromethylbenzene boronic acide and 3b by following the procedure in example 3c. This compound is a white solid: MS (ES) 323 (M+H)+; 1H NMR (400 MHz, CD3OD)δ7.80 (d, 2 H, J=8.2 Hz), 7.72 (d, 2 H, J=8.2 Hz), 7.02 (s, 1 H).

Sources & evidence

ORD record
ord-f99bab3b516f48e3b76385a42acaf7d5
Source dataset
uspto-grants-2007_01
Patent number
US07166639B2

Reaction notes

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