Diethyl Ether → HCID 86598628, compound

HRID 1375064Notes

Reaction equation

HRID 1375064 reaction equation
C(OC([NH:8][C@H:9]([C:17]1[O:21][CH:20]=[N:19][C:18]=1[C:22]([O:24][CH3:25])=[O:23])[CH2:10][C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1)=O)(C)(C)C.C(OCC)C.[F:31][C:32]([F:37])([F:36])[C:33]([OH:35])=[O:34]>>[F:31][C:32]([F:37])([F:36])[C:33]([OH:35])=[O:34].[NH2:8][C@H:9]([C:17]1[O:21][CH:20]=[N:19][C:18]=1[C:22]([O:24][CH3:25])=[O:23])[CH2:10][C:11]1[CH:12]=[CH:13][CH:14]=[CH:15][CH:16]=1

Participants

4

Reactant 3

HCID 3283Diethyl EtherHCID 6422Trifluoroacetic acidHCID 86598629HCID 86598629, compound

Product 1

HCID 86598628HCID 86598628, compound

Procedure

Methyl (S)-5-[1-(tert-butoxycarbonylamino)2-phenylethyl]oxazole-4-carboxylate, (Tett. Lett., 1982, 23, 235; 417 mg) was dissolved in trifluoroacetic acid (3 ml) and stood at ambient temperature for 1 hour and concentrated to give an oil. Trituration with diethyl ether gave the title compound as a white solid. (281 mg).

Workup

  1. concentrationconcentrated
  2. customto give an oil

Sources & evidence

ORD record
ord-e9c77350eb8849ebb9ae4a547ed1b274
Source dataset
uspto-grants-2007_01
Patent number
US07166636B2

Reaction notes

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