反应详情

A stirred solution of [1-(4-nitro-phenyl)-cyclopentyl]-acetic acid tert-butyl ester [1.0 g, Reference Example 6(a)] in methanol (40 mL) was treated with water (40 mL), ammonium chloride (0.87 g) and iron powder (325 mesh, 0.55 g). The mixture was stirred at gentle reflux for 2.5 hours and then the hot mixture was filtered through hyflo. The filter pad was washed well with methanol. The combined filtrate and washings was evaporated and the residue was partitioned between ethyl acetate and water. The organic phase was dried over magnesium sulfate and then evaporated to give the title compound (0.63 g) as a golden oil.

1. temperatureat gentle reflux for 2.5 hours
2. filtrationthe hot mixture was filtered through hyflo
3. washThe filter pad was washed well with methanol
4. customThe combined filtrate and washings was evaporated
5. customthe residue was partitioned between ethyl acetate and water
6. dry with materialThe organic phase was dried over magnesium sulfate
7. customevaporated