Trifluoroacetic acid → HCID 69908100, compound

Participants

Reaction Conditions

Reaction Steps

[1-(4-(Benzhydryl-amino)-phenyl)-indan-1-yl]-acetic acid methyl ester [(0.15 g, Reference Example 19(b)] was treated with a mixture of trifluoroacetic acid (9 mL) and water (1 mL). The resulting deep red solution was stirred at 50° C., under argon, for 2 hours and then evaporated. The residue was chased with toluene (25 mL) and then placed under vacuum to give the title compound (0.19 g) as a red gum. LC-MS: RT=2.54 minutes, MS(ES+): 282(M+H)+. This material was used immediately for the preparation of Reference Example 9(b).

Provenance & Evidence