Trifluoroacetic acid → HCID 69908100, compound

HRID 1375090Notes

Reaction equation

[CH3:1][O:2][C:3](=[O:34])[CH2:4][C:5]1([C:14]2[CH:19]=[CH:18][C:17]([NH:20]C(C3C=CC=CC=3)C3C=CC=CC=3)=[CH:16][CH:15]=2)[C:13]2[C:8](=[CH:9][CH:10]=[CH:11][CH:12]=2)[CH2:7][CH2:6]1.FC(F)(F)C(O)=O>O>[CH3:1][O:2][C:3](=[O:34])[CH2:4][C:5]1([C:14]2[CH:15]=[CH:16][C:17]([NH2:20])=[CH:18][CH:19]=2)[C:13]2[C:8](=[CH:9][CH:10]=[CH:11][CH:12]=2)[CH2:7][CH2:6]1

Participants

Conditions

Temperature: 50 °C

Procedure

[1-(4-(Benzhydryl-amino)-phenyl)-indan-1-yl]-acetic acid methyl ester [(0.15 g, Reference Example 19(b)] was treated with a mixture of trifluoroacetic acid (9 mL) and water (1 mL). The resulting deep red solution was stirred at 50° C., under argon, for 2 hours and then evaporated. The residue was chased with toluene (25 mL) and then placed under vacuum to give the title compound (0.19 g) as a red gum. LC-MS: RT=2.54 minutes, MS(ES+): 282(M+H)+. This material was used immediately for the preparation of Reference Example 9(b).

Workup

customevaporated

Sources & evidence

ORD record: ord-f8825a48bb8a4585b06dd25cbae91e51
Source dataset: uspto-grants-2007_01
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07166616B2

Reaction notes

Loading…