Acetylacetone → 3-Acetylheptane-2,6-dione

HRID 1375110Notes

Reaction equation

HRID 1375110 reaction equation
[CH3:1][C:2](=[O:7])[CH2:3][C:4](=[O:6])[CH3:5]>C(N(CC)CC)C.CC(=O)CC>[C:4]([CH:3]([CH2:2][CH2:3][C:4](=[O:6])[CH3:5])[C:2](=[O:7])[CH3:1])(=[O:6])[CH3:5]

Participants

4

Reactant 1

HCID 31261Acetylacetone

Product 1

HCID 983523-Acetylheptane-2,6-dioneYield 61.6%

Reagents, catalysts & solvents 2

HCID 8471TriethylamineCatalystHCID 6569Methyl Ethyl KetoneSolvent

Procedure

60 g of 2,4-pentandione and 0.1 g of triethyl amine were mixed, and 28 g of 2-butanone was added dropwise at room temperature. The mixture was stirred for 42 hours and the raw product was distilled off. Re-distillation gave 31.4 g of 3-acetyl-2,6-heptandione.

Workup

  1. distillationthe raw product was distilled off

Sources & evidence

ORD record
ord-e3e98ded937341ea81f2734969216961
Source dataset
uspto-grants-2007_01
Patent number
US07166648B2

Reaction notes

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