反应详情

To a mixture of 70 g of 2,4-pentandione and 1.72 g of trioctyl phosphine, 45 g of ethyl acrylate was added dropwise over 40 minutes, keeping the temperature at 0–5° C. by cooling. After stirring for 65 hours, 2 ml of acetic acid and 150 ml of diethyl ether were added, and the solution was extracted with an aqueous sodium carbonate solution and water. The organic layer was dried, and 4-acetyl-5-oxohexanoic acid ethyl ester was isolated by fractional distillation.

1. additionwas added dropwise over 40 minutes
2. customat 0–5° C.
3. temperatureby cooling
4. extractionthe solution was extracted with an aqueous sodium carbonate solution and water
5. customThe organic layer was dried