反应详情

To a solution obtained by dissolving 4.4 g of 4,4-dimethyl-3-(phenylsulfonyl)-cyclohexan-1-one in 45 ml of benzene, were added 1.1 ml of 1,2-ethanediol and 0.3 g of anhydrous paratoluenesulfonic acid. The resulting mixture was heated under reflux for 4 hours. After the reaction, a 2M aqueous sodium bicarbonate solution was added and the resulting mixture was extracted with ethyl acetate three times. The combined organic layers were washed with saturatd saline and dried over magnesium sulfate. The solvent was distilled off under reduced pressure, followed by recrystallization from ethyl ether, whereby 4,4-dimethyl-1,1 (ethylenedioxy)-3-(phenylsulfonyl)-cyclohexane was obtained in the form of white crystals. Yield: 84%, Melting point: 113 to 115° C.

1. customTo a solution obtained
2. temperatureThe resulting mixture was heated
3. temperatureunder reflux for 4 hours
4. customAfter the reaction
5. extractionthe resulting mixture was extracted with ethyl acetate three times
6. washThe combined organic layers were washed with saturatd saline
7. dry with materialdried over magnesium sulfate
8. distillationThe solvent was distilled off under reduced pressure
9. customfollowed by recrystallization from ethyl ether