Sodium hydride → HCID 11449298, compound

HRID 1375216Notes

Reaction equation

HRID 1375216 reaction equation
[CH3:1][O:2][C:3]([C:5]1([CH2:12][C:13]2[CH:18]=[CH:17][C:16]([Cl:19])=[CH:15][CH:14]=2)[CH2:9][CH2:8][CH:7]([CH3:10])[C:6]1=[O:11])=[O:4].[CH2:20]([O:22][C:23]([C:25]1([CH2:32][C:33]2[CH:38]=[CH:37][C:36]([Cl:39])=[CH:35][CH:34]=2)[CH2:29][CH2:28][CH:27]([CH3:30])[C:26]1=[O:31])=[O:24])[CH3:21].[H-].[Na+]>>[CH3:1][O:2][C:3]([C:5]1([CH2:12][C:13]2[CH:14]=[CH:15][C:16]([Cl:19])=[CH:17][CH:18]=2)[CH2:9][CH2:8][C:7]([CH3:20])([CH3:10])[C:6]1=[O:11])=[O:4].[CH2:20]([O:22][C:23]([C:25]1([CH2:32][C:33]2[CH:38]=[CH:37][C:36]([Cl:39])=[CH:35][CH:34]=2)[CH2:29][CH2:28][C:27]([CH3:1])([CH3:30])[C:26]1=[O:31])=[O:24])[CH3:21]

Participants

5

Reactant 3

HCID 24758Sodium hydrideHCID 11482916115851-54-2HCID 694133051-[(4-Chlorophenyl)methyl]-3-methyl-2-oxocyclopentanecarboxylic acid ethyl ester

Product 2

HCID 11449298HCID 11449298, compoundHCID 694130431-[(4-Chlorophenyl)methyl]-3,3-dimethyl-2-oxocyclopentanecarboxylic acid ethyl ester

Procedure

reacting 1-[(4-chlorophenyl)methyl]-3-methyl-2-oxocyclopentanecarboxylic acid methyl ester or 1-[(4-chlorophenyl)methyl]-3-methyl-2-oxocyclopentanecarboxylic acid ethyl ester with sodium hydride and methyl halide to obtain 1-[(4-chlorophenyl)methyl]-3,3-dimethyl-2-oxocyclopentanecarboxylic acid methyl ester or 1-[(4-chlorophenyl)methyl]-3,3-dimethyl-2-oxocyclopentanecarboxylic acid ethyl ester; and

Sources & evidence

ORD record
ord-f2654aab614b4495bee3ca7e9a6da088
Source dataset
uspto-grants-2007_01
Patent number
US07166750B1

Reaction notes

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