HRID1375216

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID24758

Sodium hydride

HNa

HCID11482916

未命名化合物

HCID69413305

未命名化合物

PRODUCTS

生成物

结构：COC(=O)C1(Cc2ccc(Cl)cc2)CCC(C)(C)C1=O

HCID11449298

未命名化合物

结构：CCOC(=O)C1(Cc2ccc(Cl)cc2)CCC(C)(C)C1=O

HCID69413043

未命名化合物

PROCEDURE

实验过程

reacting 1-[(4-chlorophenyl)methyl]-3-methyl-2-oxocyclopentanecarboxylic acid methyl ester or 1-[(4-chlorophenyl)methyl]-3-methyl-2-oxocyclopentanecarboxylic acid ethyl ester with sodium hydride and methyl halide to obtain 1-[(4-chlorophenyl)methyl]-3,3-dimethyl-2-oxocyclopentanecarboxylic acid methyl ester or 1-[(4-chlorophenyl)methyl]-3,3-dimethyl-2-oxocyclopentanecarboxylic acid ethyl ester; and

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-f2654aab614b4495bee3ca7e9a6da088
来源数据集: uspto-grants-2007_01
DOI: 10.6084/m9.figshare.5104873.v1
专利: US07166750B1
来源说明: uspto-grants-2007_01

反应 SMILES

[CH3:1][O:2][C:3]([C:5]1([CH2:12][C:13]2[CH:18]=[CH:17][C:16]([Cl:19])=[CH:15][CH:14]=2)[CH2:9][CH2:8][CH:7]([CH3:10])[C:6]1=[O:11])=[O:4].[CH2:20]([O:22][C:23]([C:25]1([CH2:32][C:33]2[CH:38]=[CH:37][C:36]([Cl:39])=[CH:35][CH:34]=2)[CH2:29][CH2:28][CH:27]([CH3:30])[C:26]1=[O:31])=[O:24])[CH3:21].[H-].[Na+]>>[CH3:1][O:2][C:3]([C:5]1([CH2:12][C:13]2[CH:14]=[CH:15][C:16]([Cl:19])=[CH:17][CH:18]=2)[CH2:9][CH2:8][C:7]([CH3:20])([CH3:10])[C:6]1=[O:11])=[O:4].[CH2:20]([O:22][C:23]([C:25]1([CH2:32][C:33]2[CH:38]=[CH:37][C:36]([Cl:39])=[CH:35][CH:34]=2)[CH2:29][CH2:28][C:27]([CH3:1])([CH3:30])[C:26]1=[O:31])=[O:24])[CH3:21]