1-Butanol → n-Butylphosphorodichloridate
Reaction equation
[CH2:1]([OH:5])[CH2:2][CH2:3][CH3:4].[O:6]=[P:7](Cl)([Cl:9])[Cl:8]>C(Cl)Cl>[P:7]([Cl:9])([Cl:8])([O:5][CH2:1][CH2:2][CH2:3][CH3:4])=[O:6]Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Conditions
- Temperature
- 0 °C
Procedure
To a solution of butanol (0.98 mL, 10.0 mmol) in anhydrous CH2Cl2 (10 mL) was added dropwise POCl3 (3.0 mL, 32.0 mmol) at 0° C. After stirring at 0° C. for 1 h, the mixture was refluxed for 5 h and then followed by vacuum distillation to afford butyl dichlorophosphate.
Workup
- temperaturethe mixture was refluxed for 5 h
- distillationfollowed by vacuum distillation
Sources & evidence
- ORD record
- ord-741ee96edd9246e7866739cadb9e39d0
- Source dataset
- uspto-grants-2007_01
- Patent number
- US07166744B2
Reaction notes
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