HuagongsheHuagongshe Chemistry Print Report · For research reference only
Benzyl Alcohol → benzyl (2,4-dioxo-5-phenyl-2,3,4,5-tetrahydro-1H-1,5-benzodiazepin-1-yl)acetate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Benzyl Alcohol | HCID 244 | — |
| Reactant | p-Toluenesulfonic acid | HCID 6101 | — |
| Reactant | Ethyl acetate hexane | HCID 21226206 | — |
| Reactant | (2,4-dioxo-5-phenyl-2,3,4,5-tetrahydro-1H-1,5-benzodiazepin-1-yl)acetic acid | HCID 69427552 | — |
| Solvent | Toluene | HCID 1140 | — |
| Product | benzyl (2,4-dioxo-5-phenyl-2,3,4,5-tetrahydro-1H-1,5-benzodiazepin-1-yl)acetate | HCID 86602390 | 92% |
Reaction Steps
(2,4-dioxo-5-phenyl-2,3,4,5-tetrahydro-1H-1,5-benzodiazepin-1-yl)acetic acid (8.0 g, 25.78 mM) and benzyl alcohol (3.35 g, 31 mM) were dissolved in 200 ml of toluene and 0.5 g of p-toluenesulfonic acid were added and resulting mixture was refluxed until TLC (Hexane/AcOEt 8/12) showed completion of reaction. Organic layer was washed 3 times with sodium bicarbonate solution, dried and toluene evaporated providing 9.5 g of product.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07169773B2 |
| Source dataset | uspto-grants-2007_01 |
| ORD ID | ord-62f4f3f0b99a4184aa66847338d75331 |
| Source note | uspto-grants-2007_01 |