4-(Methylamino)-2-[(4-morpholinophenyl)amino]-5-nitropyrimidine → 5-Amino-4-(methylamino)-2-[[4-(morpholin-4-yl)phenyl]amino]pyrimidine

HRID 1375398Notes

Reaction equation

HRID 1375398 reaction equation
[CH3:1][NH:2][C:3]1[C:8]([N+:9]([O-])=O)=[CH:7][N:6]=[C:5]([NH:12][C:13]2[CH:18]=[CH:17][C:16]([N:19]3[CH2:24][CH2:23][O:22][CH2:21][CH2:20]3)=[CH:15][CH:14]=2)[N:4]=1>[Pd]>[NH2:9][C:8]1[C:3]([NH:2][CH3:1])=[N:4][C:5]([NH:12][C:13]2[CH:18]=[CH:17][C:16]([N:19]3[CH2:20][CH2:21][O:22][CH2:23][CH2:24]3)=[CH:15][CH:14]=2)=[N:6][CH:7]=1

Participants

3

Reactant 1

HCID 210775724-(Methylamino)-2-[(4-morpholinophenyl)amino]-5-nitropyrimidine

Product 1

HCID 587868125-Amino-4-(methylamino)-2-[[4-(morpholin-4-yl)phenyl]amino]pyrimidine

Reagents, catalysts & solvents 1

HCID 23938PalladiumCatalyst

Procedure

Hydrogenation of 4-(methylamino)-2-[(4-morpholinophenyl)amino]-5-nitropyrimidine (from Example 2(1) above) over palladium on charcoal (Pd/C) gave the title compound as a solid.

Sources & evidence

ORD record
ord-45b8ce954717485cac39ca91bb707f8e
Source dataset
uspto-grants-2007_01
Patent number
US07169778B2

Reaction notes

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