2-[[4-(Diethylaminocarbonyl)phenyl]amino]-4-(methylamino)-5-nitropyrimidine → 5-Amino-2-[[4-(diethylaminocarbonyl)phenyl]amino]-4-(methylamino)pyrimidine

HRID 1375400Notes

Reaction equation

HRID 1375400 reaction equation
[CH2:1]([N:3]([CH2:24][CH3:25])[C:4]([C:6]1[CH:11]=[CH:10][C:9]([NH:12][C:13]2[N:18]=[C:17]([NH:19][CH3:20])[C:16]([N+:21]([O-])=O)=[CH:15][N:14]=2)=[CH:8][CH:7]=1)=[O:5])[CH3:2]>[Pd]>[NH2:21][C:16]1[C:17]([NH:19][CH3:20])=[N:18][C:13]([NH:12][C:9]2[CH:8]=[CH:7][C:6]([C:4]([N:3]([CH2:24][CH3:25])[CH2:1][CH3:2])=[O:5])=[CH:11][CH:10]=2)=[N:14][CH:15]=1

Participants

3

Reactant 1

HCID 587867992-[[4-(Diethylaminocarbonyl)phenyl]amino]-4-(methylamino)-5-nitropyrimidine

Product 1

HCID 587867825-Amino-2-[[4-(diethylaminocarbonyl)phenyl]amino]-4-(methylamino)pyrimidine

Reagents, catalysts & solvents 1

HCID 23938PalladiumCatalyst

Procedure

Hydrogenation of 2-[[4-(diethylaminocarbonyl)phenyl]amino]-4-(methylamino)-5-nitropyrimidine (from Example 2(3) above) over Pd/C gave the title compound as a solid.

Sources & evidence

ORD record
ord-0be54c0d505d46f39df47f3887c0f4f1
Source dataset
uspto-grants-2007_01
Patent number
US07169778B2

Reaction notes

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