HuagongsheHuagongshe Chemistry Print Report · For research reference only
Diethyl Oxalate → 8-Cyclopentyl-2-[[4-(4-methylpiperazin-1-yl)phenyl]amino]-5H,8H-pteridine-6,7-dione
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Diethyl Oxalate | HCID 7268 | — |
| Reactant | 5-Amino-4-(cyclopentylamino)-2-[[4-(4-methylpiperazin-1-yl)phenyl]amino]pyrimidine | HCID 58786815 | — |
| Solvent | Glycol monoethyl ether | HCID 8076 | — |
| Product | 8-Cyclopentyl-2-[[4-(4-methylpiperazin-1-yl)phenyl]amino]-5H,8H-pteridine-6,7-dione | HCID 9823514 | 52.2% |
Reaction Steps
A mixture of 0.367 g (1 mmol) of 5-amino-4-(cyclopentylamino)-2-[[4-(4-methylpiperazin-1-yl)phenyl]amino]pyrimidine and 5 mL (32 mmol) of diethyl oxalate in 20 mL of 2-ethoxyethanol is heated under reflux for 3 hours, and cooled, to give 0.22 g (52%) of the title compound (Compound 24): mp (EtOH) 266–270° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07169778B2 |
| Source dataset | uspto-grants-2007_01 |
| ORD ID | ord-0b07a8ac0499467183526f450cebb74c |
| Source note | uspto-grants-2007_01 |