反应详情

A mixture of 0.367 g (1 mmol) of 5-amino-4-(cyclopentylamino)-2-[[4-(4-methylpiperazin-1-yl)phenyl]amino]pyrimidine and 5 mL (32 mmol) of diethyl oxalate in 20 mL of 2-ethoxyethanol is heated under reflux for 3 hours, and cooled, to give 0.22 g (52%) of the title compound (Compound 24): mp (EtOH) 266–270° C.

1. temperatureis heated
2. temperatureunder reflux for 3 hours
3. temperaturecooled