Hydrochloric Acid → HCID 69208392, compound

HRID 1375454Notes

Reaction equation

HRID 1375454 reaction equation
[Br:1][C:2]1[CH:3]=[C:4]([NH:10][C:11]2[N:16]=[C:15]([NH:17][CH:18]3[CH2:24][CH2:23][CH2:22][CH2:21][CH2:20][CH2:19]3)[N:14]=[C:13]([N:25]([CH3:33])[CH:26]3[CH2:31][CH2:30][N:29]([CH3:32])[CH2:28][CH2:27]3)[N:12]=2)[CH:5]=[CH:6][C:7]=1[O:8][CH3:9].[ClH:34].C(OCC)C>CO>[ClH:34].[Br:1][C:2]1[CH:3]=[C:4]([NH:10][C:11]2[N:16]=[C:15]([NH:17][CH:18]3[CH2:19][CH2:20][CH2:21][CH2:22][CH2:23][CH2:24]3)[N:14]=[C:13]([N:25]([CH3:33])[CH:26]3[CH2:27][CH2:28][N:29]([CH3:32])[CH2:30][CH2:31]3)[N:12]=2)[CH:5]=[CH:6][C:7]=1[O:8][CH3:9]

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 3283Diethyl EtherHCID 21897069HCID 21897069, compound

Product 1

HCID 69208392HCID 69208392, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

To 123 (1.0 mmol) dissolved in methanol (5 mL) was added 1.0 M hydrochloric acid in diethyl ether (1.0 mL, 1 mmol). The reaction mixture was allowed to stir for about 1 hour at room temperature. The reaction mixture was then concentrated on a rotary evaporator. The resulting solid was dissolved in water, filtered and concentrated on the rotary evaporator. The sample was freeze dried under vacuum and a solid 170 (70%) was collected

Workup

  1. concentrationThe reaction mixture was then concentrated on a rotary evaporator
  2. dissolutionThe resulting solid was dissolved in water
  3. filtrationfiltered
  4. concentrationconcentrated on the rotary evaporator
  5. customdried under vacuum
  6. customa solid 170 (70%) was collected

Sources & evidence

ORD record
ord-1420eb4360a94bdb958a0a7684f6c8f1
Source dataset
uspto-grants-2007_01
Patent number
US07169784B2

Reaction notes

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