Hydrochloric Acid → HCID 69211596, compound

HRID 1375494Notes

Reaction equation

HRID 1375494 reaction equation
[CH:1]1([NH:8][C:9]2[N:14]=[C:13]([NH:15][CH2:16][CH:17]3[CH2:21][CH2:20][CH2:19][N:18]3[CH2:22][CH3:23])[N:12]=[C:11]([NH:24][C:25]3[CH:30]=[CH:29][C:28]([O:31][CH3:32])=[C:27]([F:33])[CH:26]=3)[N:10]=2)[CH2:7][CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.[ClH:34]>CO>[ClH:34].[CH:1]1([NH:8][C:9]2[N:14]=[C:13]([NH:15][CH2:16][CH:17]3[CH2:21][CH2:20][CH2:19][N:18]3[CH2:22][CH3:23])[N:12]=[C:11]([NH:24][C:25]3[CH:30]=[CH:29][C:28]([O:31][CH3:32])=[C:27]([F:33])[CH:26]=3)[N:10]=2)[CH2:7][CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 10298079HCID 10298079, compound

Product 1

HCID 69211596HCID 69211596, compoundYield 97%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

To 130 (2.285g, 5 mmol) in dry methanol (10 mL) was added HCl (5 mL, 5 mmol, 1 M in diethyl ether) and stirred at room temperature for about 1 hour. The reaction was evaporated in vacuo, dissolved in water, filtered, evaporated and then dried under vacuum overnight to afford a solid 164 (2.396 g, 97%), mp 131–133° C.; HPLC: Inertsil ODS-3V C18, 40:30:30 [KH2PO4 (0.01 M, pH 3.2):CH3OH: CH3CN], 264 nm, Rt 7.9 min, 98.2% purity.

Workup

  1. customThe reaction was evaporated in vacuo
  2. dissolutiondissolved in water
  3. filtrationfiltered
  4. customevaporated
  5. customdried under vacuum overnight

Sources & evidence

ORD record
ord-3291ed4c5169414383ae3c25f1dc3858
Source dataset
uspto-grants-2007_01
Patent number
US07169785B2

Reaction notes

Loading…