HCID 58786867, compound → HCID 21098182, compound

HRID 1375578Notes

Reaction equation

HRID 1375578 reaction equation
[C:1]([O:9][C:10]1[C:15](=[O:16])[N:14]([CH3:17])[C:13]([C:18]2([CH3:41])[CH2:23][N:22]([C:24]([O:26][C:27]([CH3:30])([CH3:29])[CH3:28])=[O:25])[CH2:21][CH2:20][N:19]2C(OCC2C=CC=CC=2)=O)=[N:12][C:11]=1[C:42]([O:44][CH3:45])=[O:43])(=[O:8])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1>CCOC(C)=O.[Pd]>[C:1]([O:9][C:10]1[C:15](=[O:16])[N:14]([CH3:17])[C:13]([C:18]2([CH3:41])[CH2:23][N:22]([C:24]([O:26][C:27]([CH3:29])([CH3:30])[CH3:28])=[O:25])[CH2:21][CH2:20][NH:19]2)=[N:12][C:11]=1[C:42]([O:44][CH3:45])=[O:43])(=[O:8])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Participants

4

Reactant 1

HCID 58786867HCID 58786867, compound

Product 1

HCID 21098182HCID 21098182, compound

Reagents, catalysts & solvents 2

HCID 8857Ethyl AcetateSolventHCID 23938PalladiumSolvent

Procedure

1-Benzyl 4-tert-butyl 2-[5-(benzoyloxy)-4-(methoxycarbonyl)-1-methyl-6-oxo-1,6-dihydropyrimidin-2-yl]-2-methylpiperazine-1,4-dicarboxylate was dissolved in AcOEt (20 ml/mmol) and hydrogenated at atm pressure on 10% (w/w) Pd/C over night. After filtration of the catalyst, solvent was evaporated to give crude product.

Workup

  1. filtrationAfter filtration of the catalyst, solvent
  2. customwas evaporated
  3. customto give crude product

Sources & evidence

ORD record
ord-10c528558a494f6eb0b73e97f338a2d0
Source dataset
uspto-grants-2007_01
Patent number
US07169780B2

Reaction notes

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