[3-(2-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)phenyl]-carbamic acid, 1,1-dimethylethyl ester → 3-(5-Methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)benzenamine

HRID 1375610Notes

Reaction equation

HRID 1375610 reaction equation
[CH3:1][C:2]1[N:6]([C:7]2[CH:8]=[C:9]([NH:17]C(=O)OC(C)(C)C)[CH:10]=[C:11]([C:13]([F:16])([F:15])[F:14])[CH:12]=2)[CH:5]=[N:4][CH:3]=1.CC1N(C2C=C(NC(=O)OC(C)(C)C)C=C(C(F)(F)F)C=2)C=CN=1>>[CH3:1][C:2]1[N:6]([C:7]2[CH:12]=[C:11]([C:13]([F:16])([F:14])[F:15])[CH:10]=[C:9]([NH2:17])[CH:8]=2)[CH:5]=[N:4][CH:3]=1

Participants

3

Reactant 2

HCID 86605432[3-(2-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)phenyl]-carbamic acid, 1,1-dimethylethyl esterHCID 86606803[3-(5-Methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)phenyl]-carbamic acid, 1,1-dimethylethyl ester

Product 1

HCID 591542313-(5-Methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)benzenamine

Procedure

Utilising the procedure described in Example 91d, but employing [3-(5-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)phenyl]-carbamic acid, 1,1-dimethylethyl ester (Example 93c) in lieu of [3-(2-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)phenyl]-carbamic acid, 1,1-dimethylethyl ester, afforded the title compound as a colourless crystalline solid, m.p. 131–133° C.

Sources & evidence

ORD record
ord-39d28372e2424da98c617c711cf75c12
Source dataset
uspto-grants-2007_01
Patent number
US07169791B2

Reaction notes

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