HCID 69507945, compound → HCID 10250245, compound

HRID 1375658Notes

Reaction equation

OC1C(C(OC)=O)=C(C=CC=1)OC/C=C/C1C=C(C2ON=C(C(OCC)=O)C=2)C=CC=1.[OH:32][C:33]1[C:34]([C:59]([O:61][CH3:62])=[O:60])=[C:35]([CH:56]=[CH:57][CH:58]=1)[O:36][CH2:37][CH2:38][NH:39][C:40]1[CH:41]=[C:42]([C:46]2[O:50][N:49]=[C:48]([C:51]([O:53]CC)=[O:52])[CH:47]=2)[CH:43]=[CH:44][CH:45]=1>>[OH:32][C:33]1[C:34]([C:59]([O:61][CH3:62])=[O:60])=[C:35]([CH:56]=[CH:57][CH:58]=1)[O:36][CH2:37][CH2:38][NH:39][C:40]1[CH:41]=[C:42]([C:46]2[O:50][N:49]=[C:48]([C:51]([OH:53])=[O:52])[CH:47]=2)[CH:43]=[CH:44][CH:45]=1

Participants

Reactant 2

HCID 69507945HCID 69507945, compound

HCID 69508106HCID 69508106, compound

Product 1

HCID 10250245HCID 10250245, compound

Procedure

The titled compound was prepared according to the procedure described in Example 1F, substituting the ester from Example 1E for the ester from Example 3C. MS (ESI(+)) m/e 399 (M+H)+; 1H NMR (300 MHz, DMSO-d6) δ 9.96 (s, 1H), 7.30 (s, 1H), 7.25 (t, J=8.4 Hz, 1H), 7.18 (t, J=8.4 Hz, 1H), 7.08–7.14 (m, 2H), 6.78 (dt, J=6.9, 1.5 Hz, 1H), 6.55 (d, J=5.8 Hz, 1H), 6.51 (d, J=5.8 Hz, 1H), 4.12 (t, J=5.7 Hz, 2H), 3.70 (s, 3H), 3.6–3.3 (overlapping m, 2H).

Sources & evidence

ORD record: ord-63e3fe1dfe084b428ad777b68baff740
Source dataset: uspto-grants-2007_01
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07169797B2

Reaction notes

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