反应详情

KOH (571 mg, 10.2 mmol) was stirred in 5 mL of anhydrous DMSO at room temperature. 6-Bromoindole (500 mg, 2.55 mmol) was added as solid. After 30 min, 2-bromoethanol (181 μL, 2.55 mmol) was added to the green solution, which was then stirred at room temperature overnight. Water was then added and the reaction mixture was extracted with ethyl acetate (2×25 mL). The organic layer was then washed with water and brine, dried over Na2SO4, evaporated in vacuo. MPLC purification of the crude product provided the titled compound as a light brown oil (344 mg, 56% yield).

1. extractionthe reaction mixture was extracted with ethyl acetate (2×25 mL)
2. washThe organic layer was then washed with water and brine
3. dry with materialdried over Na2SO4
4. customevaporated in vacuo
5. customMPLC purification of the crude product