反应详情

1-[(2S)-3-(4-chlorobutoxycarbonyl)mercapto-2-methyl-1-oxopropyl]-L-proline (5.80 g, 0.0157 Mol) was dissolved in CH3CN (100 ml) and NaI (23.9 g, 0.160 Mol) was added to the solution. The mixture was refluxed for 7 h, then concentrated and diluted with CH2Cl2. The solid formed was filtered off and the organic phase was washed with H2O (3×50 ml), dried over sodium sulphate and evaporated under reduced pressure affording 1-[(2S)-3-(4-iodobutoxycarbonyl) mercapto-2-methyl-1-oxopropyl]-L-proline (7.10 g) as an oil that was used without further purification.

1. temperatureThe mixture was refluxed for 7 h
2. concentrationconcentrated
3. additiondiluted with CH2Cl2
4. customThe solid formed
5. filtrationwas filtered off
6. washthe organic phase was washed with H2O (3×50 ml)
7. dry with materialdried over sodium sulphate
8. customevaporated under reduced pressure