反应详情

4-(4-Nitrophenyl)-1-Butanol (2.5 g, 12.166 mmol) was dissolved in DCM (50 ml). The solution was cooled in an ice-bath. Triethylamine (2.45 ml, 15.2 mmol) was added and then methanesulfonyl chloride (1.533 g, 13.382 mmol) was dropped in. After 1 hour, the ice-bath was removed. The mixture was stirred for 4 hours more. The reaction mixture was washed with water, sodium hydrogencarbonate aqueous solution (1%) and water (×3) and dried with magnesium sulfate. The solvent was evaporated in vacuum and the desired product (3.25 g) was obtained, yield 98%.

1. temperatureThe solution was cooled in an ice-bath
2. customthe ice-bath was removed
3. washThe reaction mixture was washed with water, sodium hydrogencarbonate aqueous solution (1%) and water (×3)
4. dry with materialdried with magnesium sulfate
5. customThe solvent was evaporated in vacuum