反应详情

温度

60 °C

4-[(6,7-Dimethoxy-4-quinazolinyl)oxy]-2-fluoro-aniline (50 mg) was dissolved in chloroform (3 ml), and 2,4-difluorophenyl isocyanate (29 μl) was then added to the solution. The mixture was stirred at 60° C. overnight. The precipitated crystal was collected by filtration and was washed to give. 50 mg (yield 67%) of the title compound.

1. filtrationThe precipitated crystal was collected by filtration
2. washwas washed
3. customto give