HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1375848Generated: October 31, 2026
2,4-Difluorophenyl isocyanate → N-(2,4-Difluorophenyl)-N'-{4-[(6,7-dimethoxy-4-quinazolinyl)oxy]-2-fluorophenyl}urea
https://huagongshe.com/reaction/1375848
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | 2,4-Difluorophenyl isocyanate | HCID 593258 | — |
| Reactant | 4-((6,7-Dimethoxy-4-quinazolinyl)oxy]-2-fluoroaniline | HCID 21890274 | — |
| Solvent | Chloroform | HCID 6212 | — |
| Product | N-(2,4-Difluorophenyl)-N'-{4-[(6,7-dimethoxy-4-quinazolinyl)oxy]-2-fluorophenyl}urea | HCID 69352841 | 67% |
Reaction Steps
4-[(6,7-Dimethoxy-4-quinazolinyl)oxy]-2-fluoro-aniline (50 mg) was dissolved in chloroform (3 ml), and 2,4-difluorophenyl isocyanate (29 μl) was then added to the solution. The mixture was stirred at 60° C. overnight. The precipitated crystal was collected by filtration and was washed to give. 50 mg (yield 67%) of the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US07169789B2 |
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| Source dataset | uspto-grants-2007_01 |
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| ORD ID | ord-a50432c0d77348c29f2b2fc5a722fe48 |
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| Source note | uspto-grants-2007_01 |
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