反应详情

温度

50 °C

Imidazole (680 mg), 1-bromo-3-chloropropane (0.79 ml), tetrabutylammonium iodide (10 mg), and a 3 M aqueous sodium hydroxide solution (1 ml) were dissolved in acetone (10 ml), and the solution was stirred at 50° C. for 18 hr. Water was added to the reaction mixture, and the mixture was extracted with chloroform. The organic layer was dried over anhydrous sodium sulfate, and the solvent was removed by distillation under the reduced pressure. The residue was purified by chromatography by development with chloroform to give an intermediate (1-(3-chloropropyl)-1H-imidazole, 525 mg).

1. extractionthe mixture was extracted with chloroform
2. dry with materialThe organic layer was dried over anhydrous sodium sulfate
3. customthe solvent was removed by distillation under the reduced pressure
4. customThe residue was purified by chromatography by development with chloroform