HCID 69425740, compound → HCID 58787872, compound

HRID 1375918Notes

Reaction equation

HRID 1375918 reaction equation
C(O[CH:5]([C:22]1[CH:27]=[CH:26][C:25]([C:28]2[CH:33]=[CH:32][CH:31]=[CH:30][CH:29]=2)=[CH:24][CH:23]=1)[CH2:6][C:7]([CH2:17][O:18][C:19](=[O:21])[CH3:20])([NH:13][C:14](=[O:16])[CH3:15])[CH2:8][O:9][C:10](=[O:12])[CH3:11])(=O)C>CCO.[Pd]>[C:19]([O:18][CH2:17][C:7]([NH:13][C:14](=[O:16])[CH3:15])([CH2:6][CH2:5][C:22]1[CH:23]=[CH:24][C:25]([C:28]2[CH:33]=[CH:32][CH:31]=[CH:30][CH:29]=2)=[CH:26][CH:27]=1)[CH2:8][O:9][C:10](=[O:12])[CH3:11])(=[O:21])[CH3:20]

Participants

4

Reactant 1

HCID 69425740HCID 69425740, compound

Product 1

HCID 58787872HCID 58787872, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 702EthanolSolvent

Procedure

Acetic acid 4-acetoxy-2-acetoxymethyl-2-acetylamino-4-biphenyl-4-yl-butyl ester (5 mmol) is dissolved in EtOH (50 mL) and hydrogenated at atmospheric pressure using 10% Pd-C (10%) at room temperature for 12 h. After filtration and concentration, the crude product is obtained as a white solid and used in the next step without further purification. MS: (ES+): 398.2 (M+1)+.

Workup

  1. customat room temperature
  2. customfor 12 h
  3. filtrationAfter filtration and concentration

Sources & evidence

ORD record
ord-9923d13ff2d942aab2b518e9e60e3d2f
Source dataset
uspto-grants-2007_01
Patent number
US07169817B2

Reaction notes

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