反应详情

Triphenylphosphine (0.66 g) was added to a solution of (6-isopropylazulen-2-yl)methanol (0.5 g) in carbon tetrachloride (10.0 ml) and the mixture was refluxed with heating for 15 hours. The reaction mixture was concentrated. The residue was purified by silica gel column chromatography (n-hexane-diethyl ether) to obtain 2-(chloromethyl)-6-isopropylazulene (0.38 g).

1. temperaturethe mixture was refluxed
2. temperaturewith heating for 15 hours
3. concentrationThe reaction mixture was concentrated
4. customThe residue was purified by silica gel column chromatography (n-hexane-diethyl ether)