Azobisisobutyronitrile → HCID 58786144, compound

HRID 1375984Notes

Reaction equation

HRID 1375984 reaction equation
[C:1]([O:4][C@@H:5]1[C@@H:10]([O:11][C:12](=[O:14])[CH3:13])[C@H:9]([O:15][C:16](=[O:18])[CH3:17])[C@@H:8]([CH2:19][O:20][C:21](=[O:23])[CH3:22])[O:7][C@H:6]1[C:24]1[CH:29]=[C:28]([CH3:30])[CH:27]=[C:26]([O:31][CH2:32][CH3:33])[C:25]=1[O:34][CH2:35][CH3:36])(=[O:3])[CH3:2].[Br:37]N1C(=O)CCC1=O.N(C(C)(C)C#N)=NC(C)(C)C#N>C(Cl)(Cl)(Cl)Cl>[C:1]([O:4][C@@H:5]1[C@@H:10]([O:11][C:12](=[O:14])[CH3:13])[C@H:9]([O:15][C:16](=[O:18])[CH3:17])[C@@H:8]([CH2:19][O:20][C:21](=[O:23])[CH3:22])[O:7][C@H:6]1[C:24]1[CH:29]=[C:28]([CH2:30][Br:37])[CH:27]=[C:26]([O:31][CH2:32][CH3:33])[C:25]=1[O:34][CH2:35][CH3:36])(=[O:3])[CH3:2]

Participants

5

Reactant 3

HCID 6547AzobisisobutyronitrileHCID 67184N-bromobutanimideHCID 58786117HCID 58786117, compound

Product 1

HCID 58786144HCID 58786144, compoundYield 80.4%

Reagents, catalysts & solvents 1

HCID 5943Carbon TetrachlorideSolvent

Procedure

A suspension of (1S)-2,3,4,6-tetra-O-acetyl-1,5-anhydro-1-(2,3-diethoxy-5-methylphenyl)-D-glucitol (500 mg) and N-bromosuccinimide (209 mg) in carbon tetrachloride (10 ml) was refluxed with heating and 2,2′-azobis(isobutyronitrile) (80 mg) was added. The mixture was stirred for 30 minutes under refluxing and the reaction mixture was allowed to be cooled to room temperature. After evaporating the solvent under reduced pressure, the resulting residue was purified by silica gel column chromatography (ethyl acetate-n-hexane) to obtain (1S)-2,3,4,6-tetra-O-acetyl-1,5-anhydro-1-[5-(bromomethyl)-2,3-diethoxyphenyl]-D-glucitol (464 mg).

Workup

  1. temperaturewas refluxed
  2. temperaturewith heating
  3. temperatureunder refluxing
  4. customAfter evaporating the solvent under reduced pressure
  5. customthe resulting residue was purified by silica gel column chromatography (ethyl acetate-n-hexane)

Sources & evidence

ORD record
ord-4b210d0dc71247a4b16da69c593339fa
Source dataset
uspto-grants-2007_01
Patent number
US07169761B2

Reaction notes

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