Ethyl chloroformate → HCID 58786571, compound

HRID 1376045Notes

Reaction equation

HRID 1376045 reaction equation
[C:1]([O:5][C:6]([N:8]1[CH2:13][CH2:12][N:11]([CH:14]([C:17]2[CH:22]=[CH:21][CH:20]=[CH:19][C:18]=2[F:23])[CH2:15][NH2:16])[CH2:10][CH2:9]1)=[O:7])([CH3:4])([CH3:3])[CH3:2].Cl[C:25]([O:27][CH2:28][CH3:29])=[O:26]>>[C:1]([O:5][C:6]([N:8]1[CH2:13][CH2:12][N:11]([CH:14]([C:17]2[CH:22]=[CH:21][CH:20]=[CH:19][C:18]=2[F:23])[CH2:15][NH:16][C:25]([O:27][CH2:28][CH3:29])=[O:26])[CH2:10][CH2:9]1)=[O:7])([CH3:4])([CH3:2])[CH3:3]

Participants

3

Reactant 2

HCID 10928Ethyl chloroformateHCID 587864641,1-Dimethylethyl 4-[2-amino-1-(2-fluorophenyl)ethyl]-1-piperazinecarboxylate

Product 1

HCID 58786571HCID 58786571, compoundYield 97%

Procedure

To 4-[2-Amino-1-(2-fluoro-phenyl)-ethyl]-piperazine-1-carboxylic acid tert-butyl ester (207) (1.0 g, 3.09 mmol) was added ethyl chloroformate (15 mL) and the reaction mixture is allowed to reflux for 18 h. The reaction mixture is then concentrated to dryness yielding 1.05 g (97%)product.

Workup

  1. temperatureto reflux for 18 h
  2. concentrationThe reaction mixture is then concentrated to dryness

Sources & evidence

ORD record
ord-cba296aeb1b24871bffcadb4c4833e93
Source dataset
uspto-grants-2007_01
Patent number
US07169777B2

Reaction notes

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