HuagongsheHuagongshe Chemistry Print Report · For research reference only
Trimethylsilyl cyanide → 4-(1-Cyano-2-cyclohexyl-ethyl)-piperazine-1-carboxylic acid tert-butyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Trimethylsilyl cyanide | HCID 82115 | — |
| Reactant | tert-Butyl piperazine-1-carboxylate | HCID 143452 | — |
| Reactant | 2-Cyclohexylacetaldehyde | HCID 316627 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | 4-(1-Cyano-2-cyclohexyl-ethyl)-piperazine-1-carboxylic acid tert-butyl ester | HCID 58786388 | — |
Reaction Steps
A solution of cyclohexaneacetaldehyde (8.45 g, 66.96 mmol) and TMSCN (17.9 mL, 133.92 mmol) in MeOH was stirred for 2 h at 23° C. and N-BOC-piperazine (13.72 g, 73.66 mmol) was added. After 24 the solvent was evaporated to give the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07169777B2 |
| Source dataset | uspto-grants-2007_01 |
| ORD ID | ord-37bb2fcfb2e74a95b88a83695df3355e |
| Source note | uspto-grants-2007_01 |