Methanesulfonyl chloride → HCID 58786455, compound

HRID 1376068Notes

Reaction equation

HRID 1376068 reaction equation
[C:1]([O:5][C:6]([N:8]1[CH2:13][CH2:12][N:11]([CH:14]([CH:21]2[CH2:26][CH2:25][CH2:24][CH2:23][CH2:22]2)[CH2:15][NH:16][CH2:17][CH:18]([CH3:20])[CH3:19])[CH2:10][CH2:9]1)=[O:7])([CH3:4])([CH3:3])[CH3:2].[CH3:27][S:28](Cl)(=[O:30])=[O:29]>C(Cl)Cl>[C:1]([O:5][C:6]([N:8]1[CH2:9][CH2:10][N:11]([CH:14]([CH:21]2[CH2:22][CH2:23][CH2:24][CH2:25][CH2:26]2)[CH2:15][N:16]([CH2:17][CH:18]([CH3:20])[CH3:19])[S:28]([CH3:27])(=[O:30])=[O:29])[CH2:12][CH2:13]1)=[O:7])([CH3:3])([CH3:4])[CH3:2]

Participants

4

Reactant 2

HCID 31297Methanesulfonyl chlorideHCID 58786611HCID 58786611, compound

Product 1

HCID 58786455HCID 58786455, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent2×

Procedure

To a solution of the product from Step II (450 mg, 1.2 mmol) in CH2Cl2 (5 mL) was added TEA (0.35 mL, 2.44 mmol) and methanesulfonyl chloride (0.14 mL, 1.83 mmol). After stirring was 30 min at 23° C. the reaction was diluted with CH2Cl2 and washed with brine, dried (Na2SO4), and evaporated to give the title product as an oil. MS m/z 446.3 (M++1).

Workup

  1. washwashed with brine
  2. dry with materialdried (Na2SO4)
  3. customevaporated

Sources & evidence

ORD record
ord-02a6c48ab4594f4e806cb2acd7180164
Source dataset
uspto-grants-2007_01
Patent number
US07169777B2

Reaction notes

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