反应详情

温度

50 °C

Stir at 50° C. for 10 min. a mixture of 3-(4-pyridinylamino)-1H-indole-2-carboxylic acid (1.27 g, 5 mmol) in DMF (25 mL), and add Cs2CO3 (1.63 g, 5 mmol). After 10 min. add bromomethyl acetate (0.95 g, 6.21 mmol) and one minute thereafter quench into aqueous NH4Cl solution. Extract with EtOAc and wash the extract with aqueous NaHCO3 solution. Dry the extract (MgSO4), filter and concentrate under vacuum to give a solid. Triturate the solid with EtOAc and obtain the title compound as a solid: MS 326(M+H).

1. customthereafter quench into aqueous NH4Cl solution
2. extractionExtract with EtOAc
3. washwash the
4. extractionextract with aqueous NaHCO3 solution
5. customDry the
6. extractionextract (MgSO4)
7. filtrationfilter
8. concentrationconcentrate under vacuum
9. customto give a solid
10. customTriturate the solid with EtOAc