Cyclohexyl isocyanate → HCID 11948029, compound

HRID 1376169Notes

Reaction equation

HRID 1376169 reaction equation
[CH:1]1([N:7]=[C:8]=[O:9])[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.[NH2:10][CH2:11][CH2:12][CH2:13][N:14]1[CH2:18][CH2:17][CH2:16][CH2:15]1>C(#N)C>[CH:1]1([NH:7][C:8]([NH:10][CH2:11][CH2:12][CH2:13][N:14]2[CH2:18][CH2:17][CH2:16][CH2:15]2)=[O:9])[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1

Participants

4

Reactant 2

HCID 18502Cyclohexyl isocyanateHCID 316701-Pyrrolidinepropanamine

Product 1

HCID 11948029HCID 11948029, compound

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent

Procedure

In an argon atmosphere 10 mmol of cyclohexylisocyanate was added slowly to 10 mmol of 1-(3-aminopropyl)pyrrolidine in 10 ml of acetonitrile. The product precipitated instantly as a pure white solid. The solvent was removed under reduced pressure and the product was crystallized with oxalic acid from diethyl ether/ethanol.

Workup

  1. customThe product precipitated instantly as a pure white solid
  2. customThe solvent was removed under reduced pressure
  3. customthe product was crystallized with oxalic acid from diethyl ether/ethanol

Sources & evidence

ORD record
ord-8a9b0449871541a8b0372ee48ea48a42
Source dataset
uspto-grants-2007_01
Patent number
US07169928B2

Reaction notes

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