Potassium Iodide → HCID 11834353, compound

HRID 1376178Notes

Reaction equation

HRID 1376178 reaction equation
[NH2:1][CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7]O.Cl[C:10]1[C:19]2[C:14](=[CH:15][CH:16]=[CH:17][CH:18]=2)[N:13]=[C:12]([CH3:20])[CH:11]=1.[I-].[K+]>C(N(CC)CC)C>[CH3:20][C:12]1[CH:11]=[C:10]([NH:1][CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][N:13]2[CH2:14][CH2:19][CH2:10][CH2:11][CH2:12]2)[C:19]2[C:14](=[CH:15][CH:16]=[CH:17][CH:18]=2)[N:13]=1

Participants

5

Reactant 3

HCID 4875Potassium IodideHCID 199606-Amino-1-hexanolHCID 779734-Chloro-2-methylquinoline

Product 1

HCID 11834353HCID 11834353, compound

Reagents, catalysts & solvents 1

HCID 8471TriethylamineSolvent

Procedure

Synthesis and purification were performed according to the procedure stated in example 152 using reagents 6-aminohexanol (15 mmol), 4-chloro-2-methylquinoline (15 mmol), 5 ml of triethylamine, and catalytic amounts of potassium iodide in the first step. The final product was purified by column chromatography (eluent: ethyl acetate/triethylamine (95/5)). The solvent was removed under reduced pressure. The residue was crystallized with oxalic acid from diethyl ether/ethanol.

Workup

  1. customSynthesis and purification
  2. customThe final product was purified by column chromatography (eluent: ethyl acetate/triethylamine (95/5))
  3. customThe solvent was removed under reduced pressure
  4. customThe residue was crystallized with oxalic acid from diethyl ether/ethanol

Sources & evidence

ORD record
ord-66f4032891b64cbb86c5691fc0ed7c63
Source dataset
uspto-grants-2007_01
Patent number
US07169928B2

Reaction notes

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